I’ve been researching what bipolar does to the brain and seriously—fuck. There’s both a lot more research than my 25-year-old B.A. in Psychology could assimilate and not nearly enough. A layperson’s book on the subject is sorely needed. Here’s the gist. * There’s solid evidence that the dysfunction during depressive and manic states causes changes that persist into our baseline states. * There are several neurotransmitters involved: dopamine, norepinephrine, serotonin, GABA (gamma-aminobutyrate), glutamate, and acetylcholine at the least. And hormones that act like neurotransmitters are in the mix, too, like endorphins and oxytocin. * Brain structures yet discovered to be involved/affected include areas of the prefrontal and temporal lobes, the hippocampus, thalamus, and hypothalamus. * Bipolar affects both grey and white matter, meaning both the structural elements of the brain and the connective tissue between them. And by affects, I mean corrodes over time. There’s mor...
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